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KMID : 0379119850130040270
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Korean Journal of Mycology
1985 Volume.13 No. 4 p.270 ~ p.270
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C-1. Studies on Constituents of the Higher Fungi of Korea (LIII)
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Kim, Byong Kak
Choi, Eung Chil/Kim, Ok Nam
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Abstract
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To find antitumor components in the cultured mycelia of Lepiota procera, a protein-polysaccharide obtained from the mycelia was subjected to DEAE-Sephadex A-50 column chromatography and Sephrose-4B gel filtration. Of the fractions, the highest purified fraction C₁ was isolated and examined for antitumor activity against the solid form of sarcoma 180 in ICR mice. The inhibition ratio of fraction C₁ was 64% at the dose of 10 ㎎/㎏/day for 10 days. When the antitumor component was examined for immunopotentiating activity, it was found to increase the number of the plaques in hemolytic plaque assay and restore the suppressed delayed-type hypersensitivity reaction in tumor bearing mice up to the 89.7% of normal level. Also the antitumor activity was suppressed by treatment with carrageenan, an antimacrophage agent.
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